Penninx B W, Beekman A T, Deeg D J, van Tilburg W
EMGO Instituut, Vrije Universiteit, Amsterdam.
Tijdschr Gerontol Geriatr. 2000 Oct;31(5):211-8.
This longitudinal study examines the physical health consequences of depression among 3107 older persons (55-85 years). Major depression was defined according to DSM-III criteria in a psychiatric interview. Minor depression was defined by a Center for Epidemiologic Studies Depression score > or = 16. Health consequences were assessed by 3-year change in self-reported functional status, 3-year change in performance on objective tests, and risk of death over 4.5 years. At baseline, 12.8% of the older persons had minor depression and 2.0% major depression. Minor depression was associated with a significantly greater decline in functional status and performance and, only in men but not in women, with an increased risk of death. Major depression also increases decline in functional status and the risk of death (irrespective of sex), but was not associated with decline in physical performance. These results show that late-life depression has strong unfavorable physical health consequences. The consequences of minor depression are comparable with those of major depression.
这项纵向研究调查了3107名老年人（55至85岁）抑郁症对身体健康的影响。在精神科访谈中，根据《精神疾病诊断与统计手册》第三版标准定义重度抑郁症。轻度抑郁症由流行病学研究中心抑郁量表得分≥16定义。通过自我报告的功能状态的3年变化、客观测试表现的3年变化以及4.5年期间的死亡风险来评估健康影响。在基线时，12.8%的老年人患有轻度抑郁症，2.0%患有重度抑郁症。轻度抑郁症与功能状态和表现的显著更大下降相关，并且仅在男性而非女性中与死亡风险增加相关。重度抑郁症也会增加功能状态下降和死亡风险（无论性别），但与身体表现下降无关。这些结果表明，晚年抑郁症对身体健康有严重的不利影响。轻度抑郁症的影响与重度抑郁症相当。
