Shamsipur M, Farhadi K
Department of Chemistry, Razi University, Kermanshah, Iran.
Analyst. 2000 Sep;125(9):1639-43. doi: 10.1039/b001452o.
The oxidation of ketoconazole on a bare carbon paste electrode was studied voltammetrically. The results indicated that the process is irreversible and controlled by an adsorption-extraction process which allows the accumulation of the drug at the electrode surface. After the optimization of solution pH, accumulation variables and instrumental parameters, sensitive differential pulse and linear sweep voltammetric peaks were obtained whose peak currents were linearly proportional to the ketoconazole concentration over the ranges 2.4 x 10(-8)-4.8 x 10(-7) and 9.1 x 10(-7)-1.0 x 10(-5) M, respectively. Based on these findings, a simple procedure was developed for the determination of ketoconazole in human urine and formulations.
采用伏安法研究了酮康唑在裸碳糊电极上的氧化过程。结果表明，该过程是不可逆的，受吸附-萃取过程控制，这使得药物能够在电极表面富集。在优化溶液pH值、富集变量和仪器参数后，获得了灵敏的差分脉冲和线性扫描伏安峰，其峰电流分别在2.4×10⁻⁸ - 4.8×10⁻⁷ M和9.1×10⁻⁷ - 1.0×10⁻⁵ M范围内与酮康唑浓度呈线性比例关系。基于这些发现，开发了一种简单的方法用于测定人尿和制剂中的酮康唑。
