Fehring T K, Odum S, Calton T F, Mason J B
Charlotte Orthopedic Research Institute and Charlotte Orthopedic Specialists Hip and Knee Center, NC, USA.
Clin Orthop Relat Res. 2000 Nov(380):9-16. doi: 10.1097/00003086-200011000-00003.
Antibiotic laden spacer blocks frequently are used to treat an infected total knee arthroplasty. Static spacer blocks make exposure at reimplantation difficult secondary to quadriceps shortening. Unexpected bone loss attributable to migration of the spacer block also has been reported. To avoid these problems, a temporary articulating molded implant made of antibiotic cement was used in a consecutive series. The authors sought to determine whether its use would affect the reinfection rate, improve functional results, or prevent bone loss compared with static spacers. Twenty-five patients were treated with static nonarticulating spacers. Since 1996, 30 patients have been treated with tobramycin-laden articulating spacers. The knee arthroplasties in three patients treated with a static spacer became reinfected (12%). The knee arthroplasty in one patient with an articulating spacer became reinfected (7%). Fifteen of the 25 patients with static spacers had unexpected bone loss between stages. No appreciable bone loss could be measured in the patients who received articulating spacers. The average Hospital for Special Surgery score was 83 points in the patients with static spacers and 84 points for the patients with articulating spacers. Range of motion at final followup averaged 98 degrees in the patients who received static spacers and 105 degrees in the patients who received articulating spacers. Articulating spacers seem to facilitate reimplantation of infected total knee arthroplasty without additional risk of infection. Unexpected bone loss is no longer a concern with this two-stage technique. Articulating spacers offered no functional advantage over static spacers in this study group.
载抗生素的间隔块常用于治疗感染性全膝关节置换术。静态间隔块会导致股四头肌缩短,使得再次植入时的暴露变得困难。也有报道称间隔块移位会导致意外的骨质流失。为避免这些问题,在一系列连续病例中使用了由抗生素骨水泥制成的临时关节成型植入物。作者试图确定与静态间隔块相比,其使用是否会影响再感染率、改善功能结果或防止骨质流失。25例患者接受了静态非关节间隔块治疗。自1996年以来,30例患者接受了含妥布霉素的关节间隔块治疗。接受静态间隔块治疗的3例患者的膝关节置换术再次感染(12%)。接受关节间隔块治疗的1例患者的膝关节置换术再次感染(7%)。25例接受静态间隔块治疗的患者中有15例在两个阶段之间出现意外骨质流失。接受关节间隔块治疗的患者中未检测到明显的骨质流失。接受静态间隔块治疗的患者的特殊外科医院平均评分为83分,接受关节间隔块治疗的患者为84分。接受静态间隔块治疗的患者在最终随访时的平均活动范围为98度,接受关节间隔块治疗的患者为105度。关节间隔块似乎有助于感染性全膝关节置换术的再次植入,且无额外的感染风险。对于这种两阶段技术,意外骨质流失不再是一个问题。在该研究组中,关节间隔块与静态间隔块相比没有功能优势。