Ivarsson A, Persson L A, Hernell O
Department of Clinical Science, Paediatrics, Umeå University, Sweden.
Adv Exp Med Biol. 2000;478:139-49. doi: 10.1007/0-306-46830-1_12.
Coeliac disease, or permanent gluten sensitive enteropathy, has emerged as a widespread health problem. It is considered an immunological disease, possibly of autoimmune type, albeit strictly dependent on the presence in the diet of wheat gluten and similar proteins from rye and barley. There are reasons to believe that the aetiology of coeliac disease is multifactorial, i.e. that other environmental exposures than the mere presence in the diet of gluten affect the disease process. Our studies have shown that prolonged breast-feeding, or perhaps even more important, ongoing breast-feeding during the period when gluten-containing foods are introduced into the diet, reduce the risk for coeliac disease. The amount of gluten consumed is also of importance in as much as larger amounts of gluten-containing foods increase the risk for coeliac disease, while it still is uncertain if the age for introducing gluten into the diet of infants is important. Thus, a challenging possibility, that need to be further explored, is if the coeliac enteropathy can be postponed, or possibly even prevented for the entire life span, by favourable dietary habits early in life.
乳糜泻，即永久性麸质敏感性肠病，已成为一个普遍的健康问题。它被认为是一种免疫性疾病，可能属于自身免疫类型，尽管严格依赖于饮食中存在小麦麸质以及黑麦和大麦中的类似蛋白质。有理由相信乳糜泻的病因是多因素的，即除了饮食中仅存在麸质之外，其他环境暴露也会影响疾病进程。我们的研究表明，延长母乳喂养时间，或者甚至更重要的是，在将含麸质食物引入饮食的时期持续进行母乳喂养，会降低患乳糜泻的风险。摄入的麸质量也很重要，因为大量含麸质食物会增加患乳糜泻的风险，而婴儿引入麸质饮食的年龄是否重要仍不确定。因此，一个具有挑战性且需要进一步探索的可能性是，乳糜泻是否可以通过生命早期良好的饮食习惯被推迟，甚至可能终生预防。
