Moroni M, Medina F, Lazzarin A, Montinari F
Boll Ist Sieroter Milan. 1975 Nov 20;54(5):393-9.
T and B-dependent systems are correlated between themselves and with the macrophage system in eliciting the immune humoral response. Not all immunogens require T-B interactions to elicit the antibody response: consequently, the problem of the limits of T-dependence, with regard to different immunogen stimulations, remains open. The comparative study of the serum antibody response in mice, thymectomized at birth and in the normal ones, inferred from the values of bactericidal activity (b.a.), detected versus E. coli, S. typhi and S. albus strains did point out evident variation. Thymectomy has impaired b.a. against E. coli; it seems to have no consequence on b.a. against S. typhi; is not possible to the results of our investigation, it seems that the response to the immunogens, responsible for the so-called natural antibodies does require T-B cooperation only for some bacterial species and not for others. A higher bactericidal capacity of normal serum with regard to Gram positive as compared with Gram negative bacteria, is confirmed.
T 细胞依赖和 B 细胞依赖系统在引发免疫体液反应方面相互关联，且与巨噬细胞系统相关。并非所有免疫原都需要 T 细胞与 B 细胞相互作用来引发抗体反应：因此，关于不同免疫原刺激下 T 细胞依赖性的限度问题仍未解决。通过检测出生时切除胸腺的小鼠和正常小鼠针对大肠杆菌、伤寒杆菌和白色葡萄球菌菌株的杀菌活性（b.a.）值，对血清抗体反应进行的比较研究确实指出了明显的差异。胸腺切除损害了针对大肠杆菌的杀菌活性；似乎对针对伤寒杆菌的杀菌活性没有影响；根据我们的研究结果，对于引发所谓天然抗体的免疫原的反应，似乎仅对某些细菌种类需要 T 细胞与 B 细胞的合作，而对其他细菌种类则不需要。与革兰氏阴性菌相比，正常血清对革兰氏阳性菌具有更高的杀菌能力这一点得到了证实。
