组胺对豚鼠离体肝门静脉内皮细胞的作用及其被吲哚美辛或去除钙的影响。

Br J Exp Pathol. 1975 Feb;56(1):52-61.

Methods are described for preparing guinea-pig hepatic portal vein endothelium for light microscopy and electron microscopy. Histamine (100 mug/ml) caused damage to the endothelium which was visible with both the light and electron microscopes. The damage was reduced in the absence of calcium. The reduction was more apparent with the electron microscope than with the light microscope. Indomethacin (100 mug/ml) protected the endothelial cells against the damaging effects of histamine. Possible modes of action of histamine and indomethacin are discussed.

本文描述了制备豚鼠肝门静脉内皮用于光学显微镜和电子显微镜观察的方法。组胺（100微克/毫升）可导致内皮损伤，光学显微镜和电子显微镜下均可见。在无钙情况下损伤减轻。电子显微镜下的减轻比光学显微镜下更明显。吲哚美辛（100微克/毫升）可保护内皮细胞免受组胺的损伤作用。文中讨论了组胺和吲哚美辛可能的作用方式。