Panczenko B, Grodzińska L, Gryglewski R
Pol J Pharmacol Pharm. 1975 May-Jun;27(3):273-6.
Indomethacin and meclofenamate (1 mug/ml) enhance contractile action of PGF2 alpha (5-20 mug) in guinea-pig tracheas superfused with Tyrode solution (5 ml/min). Unlike indomethacin, meclofenamate at a concentration of 10 mug/ml antagonizes contractions of guinea-pig tracheas produced by PGF2 alpha (5-20 mug), while the contractile action of histamine (0-5-2-0 mug) is enhanced. It is concluded that low concentrations of meclofenamate (1 mug/ml) inhibit prostaglandin biosynthesis in tracheal smooth muscles and therefore contractile action of exogenous PGF2 alpha is enhanced, while meclofenamate at a high concentration (10 mug/ml) blocks the receptor sites for PGF2 alpha.
吲哚美辛和甲氯芬那酸（1微克/毫升）可增强豚鼠气管中PGF2α（5 - 20微克）在以台氏液（5毫升/分钟）灌注时的收缩作用。与吲哚美辛不同，浓度为10微克/毫升的甲氯芬那酸可拮抗PGF2α（5 - 20微克）引起的豚鼠气管收缩，同时增强组胺（0.5 - 2.0微克）的收缩作用。结论是低浓度的甲氯芬那酸（1微克/毫升）抑制气管平滑肌中前列腺素的生物合成，因此增强了外源性PGF2α的收缩作用，而高浓度（10微克/毫升）的甲氯芬那酸则阻断了PGF2α的受体位点。
