肾衰竭患者使用低剂量秋水仙碱的风险

Dangers of low-dose colchicine in patients with renal failure.

出版信息

Prescrire Int. 2000 Aug;9(48):116.

Abstract

(1) Life-threatening colchicine intoxication can occur in patients with renal failure, even with low-dose regimens. (2) Diarrhoea, nausea and vomiting are the first manifestations of overdose. Colchicine must be withdrawn immediately to avoid severe complications (especially haematological and neuromuscular). (3) Colchicine must not be prescribed without first assessing creatinine clearance (using the Cockroft formula, for example), especially in elderly patients.

摘要

（1）即使采用低剂量方案，肾衰竭患者也可能发生危及生命的秋水仙碱中毒。（2）腹泻、恶心和呕吐是过量用药的首发表现。必须立即停用秋水仙碱以避免严重并发症（尤其是血液学和神经肌肉方面的并发症）。（3）在未首先评估肌酐清除率（例如使用 Cockroft 公式）的情况下，不得开具秋水仙碱处方，尤其是老年患者。