[秋水仙碱的多系统毒性与肾衰竭：关于一例病例]
[Multi-systemic toxicity of colchicine and renal failure: apropos of a case].
作者信息
Rosset L, Descombes E, Fellay G, Regamey C
机构信息
Clinique de médecine interne, Hôpital cantonal, Fribourg.
出版信息
Schweiz Med Wochenschr. 1998 Dec 5;128(49):1953-7.
PMID:9887475
Abstract
The use of colchicine can produce various side effects, but multiorgan toxicity is rare. We report the first Swiss case of multiorgan toxicity involving typical neuromuscular lesions. Muscular biopsy is a valuable tool in confirming the diagnosis. Renal insufficiency and hepatobiliary diseases are predisposing factors for such complications. Colchicine pharmacology in the case of renal insufficiency is discussed.
摘要
秋水仙碱的使用会产生多种副作用，但多器官毒性较为罕见。我们报告了瑞士首例涉及典型神经肌肉病变的多器官毒性病例。肌肉活检是确诊的重要手段。肾功能不全和肝胆疾病是此类并发症的诱发因素。本文还讨论了肾功能不全情况下秋水仙碱的药理学。
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