Rosset L, Descombes E, Fellay G, Regamey C
Clinique de médecine interne, Hôpital cantonal, Fribourg.
Schweiz Med Wochenschr. 1998 Dec 5;128(49):1953-7.
The use of colchicine can produce various side effects, but multiorgan toxicity is rare. We report the first Swiss case of multiorgan toxicity involving typical neuromuscular lesions. Muscular biopsy is a valuable tool in confirming the diagnosis. Renal insufficiency and hepatobiliary diseases are predisposing factors for such complications. Colchicine pharmacology in the case of renal insufficiency is discussed.
秋水仙碱的使用会产生多种副作用，但多器官毒性较为罕见。我们报告了瑞士首例涉及典型神经肌肉病变的多器官毒性病例。肌肉活检是确诊的重要手段。肾功能不全和肝胆疾病是此类并发症的诱发因素。本文还讨论了肾功能不全情况下秋水仙碱的药理学。
