Prescrire Int. 2000 Aug;9(48):117-22.
(1) Drug-induced cutaneous photosensitivity is defined as excessive or abnormal skin reactions to light, linked to systemic or topical administration of a drug. (2) The lesions appear after exposure to sunlight or an ultraviolet source, and are limited to or predominate in exposed areas. (3) Some drugs can induce occasionally severe skin burns after moderate exposure to sunlight. Other types of drug-related skin lesion include eczematous or urticarial eruptions, pseudoporphyria, abnormal pigmentation and pseudolichen. Photo-induced or photo-aggravated contact dermatitis can occur after application of a photosensitising drug. (4) Some drugs are particularly photosensitising, such as psoralens, tetracyclines, amiodarone and quinolones. (5) Patients treated with drugs known to cause cutaneous photosensitivity should be warned of the risk of cutaneous reactions on exposure to light and be encouraged to protect their skin from intense exposure to sunlight. (6) The possible responsibility of a drug should be borne in mind when a patient presents with skin lesions with a distribution typical of cutaneous photosensitivity. Drug withdrawal and subsequent avoidance can lead to recovery and avoid recurrences.
(1) 药物性皮肤光敏反应被定义为皮肤对光线出现过度或异常反应，这与药物的全身或局部应用有关。(2) 皮损在暴露于阳光或紫外线源后出现，且局限于暴露部位或在这些部位占主导。(3) 一些药物在适度暴露于阳光后偶尔会引起严重的皮肤灼伤。其他类型的药物相关皮肤损害包括湿疹样或荨麻疹样皮疹、假性卟啉症、色素沉着异常和假性苔藓。应用光敏药物后可发生光诱导或光加重的接触性皮炎。(4) 一些药物特别容易引起光敏反应，如补骨脂素、四环素、胺碘酮和喹诺酮类。(5) 接受已知会引起皮肤光敏反应药物治疗的患者应被告知暴露于光线下发生皮肤反应的风险，并鼓励他们保护皮肤免受强烈阳光照射。(6) 当患者出现具有皮肤光敏反应典型分布的皮肤损害时，应考虑到药物的可能作用。停药并随后避免接触可导致恢复并避免复发。
