Bastien M, Milpied-Homsi B, Baudot S, Dutartre H, Litoux P
Clinique Dermatologique, CHU Nantes.
Ann Dermatol Venereol. 1997;124(8):523-6.
Nonsteroidal antiinflammatory drugs (NSAID) are widely used in topical applications for benign diseases. Adverse skin reactions include contact eczema and photocontact dermatitis. Among the NSAID used in topical applications, arylpropionic derivatives, notably ketoprofen, are frequently implicated.
We observed 5 patients who developed eczema lesions after application of Ketum, a gel containing ketoprofen used on healthy skin after exposure to sunlight. Photoallergy explorations evidenced positive photopatch-tests for ketoprofen with UVA and total light. The anamnesis suggested a photoallergic mechanism which was confirmed by histological examination of the biopsy of a UVA positive photopatch-test and by negative photopatch-tests in 10 healthy controls.
The photosensitizing potential of ketoprofen in the UVA spectrum is well known. Although the number of adverse reactions is quite small compared with widespread use, physicians should be aware of this photosensitivity and report all cases to the pharmacovigilance center.
非甾体抗炎药（NSAID）广泛用于良性疾病的局部应用。皮肤不良反应包括接触性湿疹和光接触性皮炎。在局部应用的NSAID中，芳基丙酸衍生物，尤其是酮洛芬，经常被牵连其中。
我们观察了5例患者，他们在暴露于阳光下后，在健康皮肤上使用含酮洛芬的凝胶Ketur后出现了湿疹病变。光过敏检测证明，酮洛芬在UVA和全光谱下的光斑试验呈阳性。病史提示为光过敏机制，这通过对UVA阳性光斑试验活检的组织学检查以及10名健康对照的阴性光斑试验得到证实。
酮洛芬在UVA光谱中的光敏潜力是众所周知的。尽管与广泛使用相比，不良反应的数量相当少，但医生应意识到这种光敏性，并将所有病例报告给药物警戒中心。
