Lewit-Bentley A, Réty S, Sopkova-de Oliveira Santos J, Gerke V
LURE (CNRS, CEA, MENRT), Centre Universitaire Paris-Sud, Orsay, 91898, France.
Cell Biol Int. 2000;24(11):799-802. doi: 10.1006/cbir.2000.0629.
Several annexins have been shown to bind proteins that belong to the S100 calcium-binding protein family. The two best-characterized complexes are annexin II with p11 and annexin I with S100C, the former of which has been implicated in membrane fusion processes. We have solved the crystal structures of the complexes of p11 with annexin II N-terminus and of S100C with annexin I N-terminus. Using these structural results, as well as electron microscopy observations of liposome junctions formed in the presence of such complexes (Lambert et al., 1997 J Mol Biol 272, 42-55), we propose a computer generated model for the entire annexin II/p11 complex.
已有研究表明，几种膜联蛋白可与属于S100钙结合蛋白家族的蛋白质结合。其中研究最为充分的两种复合物是膜联蛋白II与p11以及膜联蛋白I与S100C，前者与膜融合过程有关。我们已经解析了p11与膜联蛋白II N端以及S100C与膜联蛋白I N端复合物的晶体结构。利用这些结构结果以及在此类复合物存在下形成的脂质体连接的电子显微镜观察结果（Lambert等人，1997年，《分子生物学杂志》272卷，42 - 55页），我们提出了一个关于整个膜联蛋白II/p11复合物的计算机生成模型。
