Gruart A, Guillazo-Blanch G, Fernández-Mas R, Jiménez-Díaz L, Delgado-García J M
División de Neurociencias, Laboratorio Andaluz de Biología, Universidad Pablo de Olavide, 41013 Sevilla, Spain.
J Neurophysiol. 2000 Nov;84(5):2680-90. doi: 10.1152/jn.2000.84.5.2680.
Cerebellar posterior interpositus neurons were recorded in cats during delayed and trace conditioning of eyeblinks. Type A neurons increased their firing in the time interval between conditioned and unconditioned stimulus presentations for both paradigms, while type B neurons decreased it. The discharge of different type A neurons recorded across successive conditioning sessions increased, with slopes of 0.061-0.078 spikes/s/trial. Both types of neurons modified their firing several trials in advance of the appearance of eyelid conditioned responses, but for each conditioned stimulus presentation their response started after conditioned response onset. Interpositus microstimulation evoked eyelid responses similar in amplitude and profiles to conditioned responses, and microinjection of muscimol decreased conditioned response amplitude. It is proposed that the interpositus nucleus is an enhancer, but not the initiator, of eyelid conditioned responses.
在猫的眨眼延迟条件反射和痕迹条件反射过程中，记录小脑后间位核神经元的活动。在这两种范式中，A型神经元在条件刺激和非条件刺激呈现的时间间隔内放电增加，而B型神经元放电减少。在连续的条件反射实验中记录到的不同A型神经元的放电增加，斜率为0.061 - 0.078个动作电位/秒/试验。两种类型的神经元在眼睑条件反应出现前的几次试验中就改变了它们的放电，但对于每个条件刺激呈现，它们的反应在条件反应开始后才开始。间位核微刺激诱发的眼睑反应在幅度和波形上与条件反应相似，而注射蝇蕈醇会降低条件反应幅度。有人提出，间位核是眼睑条件反应的增强器，而非启动器。
