Momose Y, Murata M, Kanazawa I
Department of Neurology, Graduate School of Medicine, University of Tokyo.
Nihon Rinsho. 2000 Oct;58(10):2061-5.
After the advent of levodopa, treatment of Parkinson's disease has changed and the activity of daily life of patients has been remarkably improved; whereas, many patients experience various problems such as wearing-off, dyskinesia, dystonia, neuropsychiatric problems, and dysautonomia. Especially, wearing-off and dyskinesia emerge with the change of absorptional pattern of levodopa and could be solved by regulating the timing and the dose of it. Recently, some new drugs for Parkinson's disease have been available and we physician have a wide choice of them. It is important to make a careful choice of and manipulate of doses of drugs after understanding daily life of each patient enough.
左旋多巴问世后，帕金森病的治疗发生了变化，患者的日常生活活动有了显著改善；然而，许多患者会出现各种问题，如剂末现象、异动症、肌张力障碍、神经精神问题和自主神经功能障碍。特别是，剂末现象和异动症会随着左旋多巴吸收模式的改变而出现，可以通过调整其服用时间和剂量来解决。最近，一些治疗帕金森病的新药已经上市，我们医生有了广泛的选择。在充分了解每位患者的日常生活情况后，谨慎选择和调整药物剂量非常重要。
