Kurokawa K, Yuasa T
Department of Neurology, Kohnodai Hospital.
Nihon Rinsho. 2000 Oct;58(10):2120-4.
Up to 40% of cases of Parkinson's disease are associated with the occurrence of depression. The symptoms of the patients' depressive state may be factors such as significant weight change, insomnia or hypersomnia, psychomotor retardation, fatigue or loss of energy, feelings of worthlessness or inappropriate guilt, decreased concentration and indecisiveness, and recurrent thoughts of death or suicidal ideation. Given these conditions, drugs prove ineffective in many cases. Electroconvulsive therapy (ECT) has been reported to be beneficial in cases of drug-resistant depression. ECT has also been applied to Parkinsonian patients with depression and found to be effective with both depression and the Parkinsonian symptom. Transcranial magnetic stimulation(TMS) has recently been investigated for application in cases of depression and has become known as a valuable tool for depression therapy. TMS is easily implemented even in outpatient therapy. TMS will make a great contribution to the therapy of depression with Parkinson's disease.
高达40%的帕金森病病例与抑郁症的发生有关。患者抑郁状态的症状可能包括显著的体重变化、失眠或嗜睡、精神运动迟缓、疲劳或精力丧失、无价值感或不适当的内疚感、注意力不集中和优柔寡断，以及反复出现的死亡念头或自杀观念等因素。鉴于这些情况，药物在许多病例中被证明无效。据报道，电休克疗法（ECT）对耐药性抑郁症病例有益。ECT也已应用于患有抑郁症的帕金森病患者，并发现对抑郁症和帕金森病症状均有效。经颅磁刺激（TMS）最近已被研究用于抑郁症病例，并已成为抑郁症治疗的一种有价值的工具。即使在门诊治疗中，TMS也很容易实施。TMS将对帕金森病伴抑郁症的治疗做出巨大贡献。
