Dam H, Pakkenberg H, Bolwig T G
Rigshospitalet, psykiatrisk afdeling O, København.
Ugeskr Laeger. 1992 Jan 20;154(4):183-7.
A case report and a review of the literature concerning electroconvulsive therapy (ECT) in the treatment of Parkinson's disease with special reference to the therapy of "on-off" phenomena is given. The first report of positive effect appeared in 1959 and, with a single exception, all published articles on this topic point to a positive outcome of ECT. There seems to be a specific anti-Parkinsonian effect alongside the well-known effect on various psychotic conditions. ECT thus must be considered a valuable intervention when drug therapy is insufficient, when prolonged medication leads to decreased efficacy, or when patients develop neuro-psychiatric manifestations. A short review of the pathophysiological mechanisms which may underly the effect of ECT in Parkinson's disease is given.
本文给出了一例病例报告，并对有关电休克疗法（ECT）治疗帕金森病，特别是治疗“开-关”现象的文献进行了综述。关于ECT产生积极效果的首次报告出现在1959年，并且除了一篇文章外，所有关于该主题的已发表文章均指出ECT有积极疗效。除了对各种精神疾病的众所周知的作用外，似乎还存在一种特定的抗帕金森病作用。因此，当药物治疗不足、长期用药导致疗效降低或患者出现神经精神表现时，ECT必须被视为一种有价值的干预措施。本文还对可能是ECT在帕金森病中发挥作用基础的病理生理机制进行了简要综述。
