Giebisch G
Yale University School of Medicine, New Haven, USA.
Nephrologie. 2000;21(5):223-8.
Potassium channels play an important role in several renal functions. These include the generation of a cell negative potential in all kidney cells, and potassium channels also participate importantly in the function of the thick ascending limb of Henle's loop and in principal tubule cells of collecting ducts. In the thick ascending limb (TAL), potassium channels mediate recycling of potassium ions across the apical membrane, thereby modulating the turnover of the Na/K/2Cl cotransporter. In the principal tubule cell, potassium channels play a key role in the secretion of potassium. The K channels in both the TAL and cortical collecting duct (CCD) have been cloned, and their functional properties are similar. Hereditary abnormalities of these K channels have been shown to lead to salt loss. Moreover, the delivery of sodium can be shown to be a key determinant of potassium secretion in the terminal nephron segment.
钾通道在多种肾脏功能中发挥着重要作用。这些功能包括在所有肾细胞中产生细胞负电位，并且钾通道在髓袢升支粗段和集合管主细胞的功能中也起着重要作用。在髓袢升支粗段（TAL），钾通道介导钾离子跨顶端膜的循环，从而调节Na/K/2Cl共转运体的周转。在主细胞中，钾通道在钾分泌中起关键作用。髓袢升支粗段和皮质集合管（CCD）中的钾通道已被克隆，并且它们的功能特性相似。已表明这些钾通道的遗传性异常会导致盐分流失。此外，钠的输送可被证明是终末肾单位段钾分泌的关键决定因素。
