Wang T, Wang W H, Klein-Robbenhaar G, Giebisch G
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.
J Pharmacol Exp Ther. 1995 Jun;273(3):1382-9.
ATP-sensitive potassium channels (KATP) modulate Na, K and Cl reabsorption in the thick ascending limb of the loop of Henle and K secretion in the cortical collecting tubule. Inhibition of potassium recycling in the apical membrane of the thick ascending limb of the loop of Henle interferes with sodium reabsorption and suppression of the apical potassium conductance in principal cells of the cortical collecting tubule and reduces potassium secretion. Both potassium recycling and potassium secretion depend critically on the activity of KATP, and recent studies indicate that the sulfonylurea compound glyburide, a known KATP channel blocker, is diuretic but does not produce kaliuresis.
ATP敏感性钾通道（KATP）调节髓袢升支粗段中钠、钾和氯的重吸收以及皮质集合管中的钾分泌。抑制髓袢升支粗段顶端膜中的钾循环会干扰钠重吸收，并抑制皮质集合管主细胞顶端钾电导，从而减少钾分泌。钾循环和钾分泌都严重依赖于KATP的活性，最近的研究表明，磺脲类化合物格列本脲是一种已知的KATP通道阻滞剂，具有利尿作用，但不会导致尿钾增多。
