Velázquez F R, Matson D O, Guerrero M L, Shults J, Calva J J, Morrow A L, Glass R I, Pickering L K, Ruiz-Palacios G M
Department of Infectious Diseases, Instituto Nacional de la Nutrición, Mexico City, Mexico.
J Infect Dis. 2000 Dec;182(6):1602-9. doi: 10.1086/317619. Epub 2000 Oct 23.
To determine whether naturally acquired serum IgA and IgG antibodies were associated with protection against rotavirus infection and illness, a cohort of 200 Mexican infants was monitored weekly for rotavirus excretion and diarrhea from birth to age 2 years. Serum samples collected during the first week after birth and every 4 months were tested for anti-rotavirus IgA and IgG. Children with an IgA titer >1:800 had a lower risk of rotavirus infection (adjusted relative risk [aRR], 0.21; P<.001) and diarrhea (aRR, 0. 16; P=.01) and were protected completely against moderate-to-severe diarrhea. However, children with an IgG titer >1:6400 were protected against rotavirus infection (aRR, 0.51; P<.001) but not against rotavirus diarrhea. Protective antibody titers were achieved after 2 consecutive symptomatic or asymptomatic rotavirus infections. These findings indicate that serum anti-rotavirus antibody, especially IgA, was a marker of protection against rotavirus infection and moderate-to-severe diarrhea.
为了确定自然获得的血清IgA和IgG抗体是否与预防轮状病毒感染及疾病有关，对200名墨西哥婴儿组成的队列从出生到2岁每周监测轮状病毒排泄情况和腹泻情况。在出生后第一周以及每4个月采集的血清样本检测抗轮状病毒IgA和IgG。IgA滴度>1:800的儿童轮状病毒感染风险较低（校正相对风险[aRR]，0.21；P<0.001）且腹泻风险较低（aRR，0.16；P=0.01），并且完全预防了中重度腹泻。然而，IgG滴度>1:6400的儿童可预防轮状病毒感染（aRR，0.51；P<0.001），但不能预防轮状病毒腹泻。在连续2次出现有症状或无症状的轮状病毒感染后达到保护性抗体滴度。这些发现表明血清抗轮状病毒抗体，尤其是IgA，是预防轮状病毒感染和中重度腹泻的一个标志物。
