Schwartz D A, Sungkarat S, Shaffer N, Laosakkitiboran J, Supapol W, Charoenpanich P, Chuangsuwanich T, Mastro T D
Departments of Pathology and Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
J Infect Dis. 2000 Dec;182(6):1652-7. doi: 10.1086/317634. Epub 2000 Nov 8.
The effects of human immunodeficiency virus (HIV) type 1 on the placenta and the role of the placenta in mother-to-child HIV-1 transmission are not well understood. Placentas from 78 HIV-infected and 158 HIV-uninfected women were examined as part of a prospective perinatal HIV transmission study in Bangkok. HIV-infected women were more likely than HIV-uninfected women to have chorioamnionitis (odds ratio [OR], 2.1; P=.03), placental membrane inflammation (PMI; OR, 2. 7; P=.02), and deciduitis (OR, 2.3; P=.03) and less likely to have villitis (OR, 0.3; P=.02). However, among HIV-infected women, fewer women who transmitted infection to their child had chorioamnionitis (relative risk [RR], 0.2; P=.03), funisitis (RR, 0.4; P=.1), or PMI (RR undefined; P=.03). These findings suggest that, in this population, HIV-infected women are at increased risk for placental membrane inflammatory lesions, but that placental inflammatory lesions are not associated with increased perinatal HIV transmission.
1型人类免疫缺陷病毒（HIV）对胎盘的影响以及胎盘在母婴HIV-1传播中的作用尚未完全明确。作为曼谷一项前瞻性围产期HIV传播研究的一部分，对78名感染HIV的女性和158名未感染HIV的女性的胎盘进行了检查。与未感染HIV的女性相比，感染HIV的女性更易发生绒毛膜羊膜炎（优势比[OR]，2.1；P = 0.03）、胎盘膜炎症（PMI；OR，2.7；P = 0.02）和蜕膜炎（OR，2.3；P = 0.03），而发生绒毛炎的可能性较小（OR，0.3；P = 0.02）。然而，在感染HIV的女性中，将感染传播给孩子的女性发生绒毛膜羊膜炎（相对风险[RR]，0.2；P = 0.03）、脐带炎（RR，0.4；P = 0.1）或PMI（RR未确定；P = 0.03）的较少。这些发现表明，在该人群中，感染HIV的女性发生胎盘膜炎性病变的风险增加，但胎盘炎性病变与围产期HIV传播增加无关。
