Kurokawa I, Kusumoto K, Bessho K, Okubo Y, Senzaki H, Tsubura A
Department of Dermatology, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17 Minamitsukaguchi-cho, Amagasaki, Hyogo 661-0012, Japan.
Br J Dermatol. 2000 Oct;143(4):754-8. doi: 10.1046/j.1365-2133.2000.03771.x.
The mechanism of occurrence of calcification and ossification in pilomatricoma remains unclear.
To elucidate the pathogenesis of calcification and ossification in pilomatricoma we examined the role of bone morphogenetic protein (BMP)-2, which plays important parts in inducing ectopic bone formation both in vivo and in vitro.
Twenty cases of pilomatricoma were studied immunohistochemically using anti-BMP-2 monoclonal antibody.
In normal skin, including hair follicles, there was no BMP-2 expression. In all pilomatricomas, BMP-2 was found exclusively in the cytoplasm of shadow cells but not in basophilic cells. In two cases of bone formation seen in pilomatricoma, osteoblasts in the periosteal area showed a strong positive reaction, while bone trabeculum (bone matrix) showed no reaction.
Our findings indicate that shadow cells positive for BMP-2 may play an important part in generating bone formation in pilomatricoma.
毛母质瘤中钙化和骨化的发生机制尚不清楚。
为阐明毛母质瘤中钙化和骨化的发病机制，我们研究了骨形态发生蛋白（BMP）-2的作用，其在体内外诱导异位骨形成中发挥重要作用。
使用抗BMP-2单克隆抗体对20例毛母质瘤进行免疫组织化学研究。
在包括毛囊在内的正常皮肤中，未发现BMP-2表达。在所有毛母质瘤中，BMP-2仅在影细胞的细胞质中发现，而在嗜碱性细胞中未发现。在毛母质瘤中观察到的两例骨形成病例中，骨膜区域的成骨细胞呈强阳性反应，而骨小梁（骨基质）无反应。
我们的研究结果表明，BMP-2阳性的影细胞可能在毛母质瘤的骨形成中起重要作用。
