Mieno Hideki, Kuroda Kei, Tajima Shingo
Department of Dermatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
J Cutan Pathol. 2005 Mar;32(3):206-11. doi: 10.1111/j.0303-6987.2005.00289.x.
We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (SCs) of pilomatricoma.
This time, we studied the expression of type II collagen and BMP in a large number of cases of pilomatricoma and extended our study to cutaneous mixed tumor (CMT).
We found type II collagen deposition in the overlying DEJ (16 of 50 cases) and in the SCs (19/50) of pilomatricoma. The number of case of type II collagen deposition in DEJ (DEJ(+)) and in SCs (SC(+)) of pilomatricoma correlated to the chronological stage of pilomatricoma. We also found type II collagen deposition in overlying DEJ (two of 11) and in the stromal chondroid tissue (four of 11) of CMT. BMP 2 was expressed in most cases of pilomatricoma (37/50) and CMT (seven of 11).
The expression of type II collagen in pilomatricoma is dependent upon the chronological stage of pilomatricoma. Type II collagen expression in the overlying DEJ and chondroid matrix in CMT may be induced by BMP via the same mechanism as in pilomatricoma.
我们之前报道过，毛母质瘤覆盖的真皮-表皮交界处（DEJ）中的II型胶原沉积是由毛母质瘤的影子细胞（SCs）表达的骨形态发生蛋白2/4（BMP 2/4）介导的。
此次，我们研究了大量毛母质瘤病例中II型胶原和BMP的表达情况，并将研究扩展至皮肤混合瘤（CMT）。
我们在毛母质瘤覆盖的DEJ（50例中有16例）和SCs（50例中有19例）中发现了II型胶原沉积。毛母质瘤DEJ（DEJ(+)）和SCs（SC(+)）中II型胶原沉积的病例数与毛母质瘤的病程阶段相关。我们还在CMT覆盖的DEJ（11例中有2例）和基质软骨样组织（11例中有4例）中发现了II型胶原沉积。大多数毛母质瘤病例（37/50）和CMT病例（11例中有7例）中表达了BMP 2。
毛母质瘤中II型胶原的表达取决于毛母质瘤的病程阶段。CMT覆盖的DEJ和软骨样基质中II型胶原的表达可能是由BMP通过与毛母质瘤相同的机制诱导的。
