Kinkelin I, Hund M, Naumann M, Hamm H
Department of Dermatology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Br J Dermatol. 2000 Oct;143(4):824-7. doi: 10.1046/j.1365-2133.2000.03839.x.
Focal hyperhidrosis is a common condition mostly confined to the axillae, palms and soles. In some individuals, predominantly men, increased sweating of the forehead may be the major complaint and may interfere with the person's quality of life. Botulinum toxin A has been shown to be a very effective treatment for focal hyperhidrosis of the axillae and palms.
To assess the response in 10 men suffering from frontal hyperhidrosis treated with botulinum toxin A.
Botulinum toxin A Botox was injected at multiple sites evenly distributed over the forehead (mean dose 86 mouse units).
The mean +/- SEM amount of sweat was significantly reduced, 4 weeks after treatment, from 173.8 +/- 38.6 mg min(-1) to 53.7 +/- 17.6 mg min(-1). The effect lasted at least 5 months in nine of the 10 patients. All patients subjectively judged the treatment as very effective. Minor side-effects included painful injections and a transient weakness of forehead muscles without ptosis.
In this study, we provide evidence that botulinum toxin A is an effective and safe treatment for frontal hyperhidrosis.
局限性多汗症是一种常见病症，主要局限于腋窝、手掌和脚底。在一些个体中，主要是男性，额头出汗增多可能是主要症状，并且可能会影响患者的生活质量。肉毒杆菌毒素A已被证明是治疗腋窝和手掌局限性多汗症的一种非常有效的方法。
评估10名患有额头多汗症的男性接受肉毒杆菌毒素A治疗后的反应。
将肉毒杆菌毒素A（保妥适）均匀注射于额头多个部位（平均剂量86鼠单位）。
治疗4周后，平均±标准误的出汗量从173.8±38.6毫克/分钟显著降至53.7±17.6毫克/分钟。10名患者中有9名患者的疗效持续至少5个月。所有患者主观判断该治疗非常有效。轻微副作用包括注射疼痛和前额肌肉短暂无力但无眼睑下垂。
在本研究中，我们提供证据表明肉毒杆菌毒素A是治疗额头多汗症的一种有效且安全的方法。
