Rönnau A C, Wulferink M, Gleichmann E, Unver E, Ruzicka T, Krutmann J, Grewe M
Department of Dermatology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany.
Br J Dermatol. 2000 Nov;143(5):1055-8. doi: 10.1046/j.1365-2133.2000.03843.x.
A 32-year-old patient developed an anaphylactic reaction minutes after oral intake of acetaminophen-containing tablets (Doregrippin)). Scratch testing of the whole preparation was positive in contrast with the negative results obtained with pure acetaminophen. Therefore, scratch tests with the remaining drug components were performed and showed polyvinylpyrrolidone (PVP) to be the aetiological agent. Furthermore, specific IgE antibodies against PVP were demonstrated using a dot blot technique, thus ruling out a pseudo-allergic reaction. This case underlines the necessity to consider not only the active ingredient, but also additives as the causative agent.
一名32岁患者在口服含对乙酰氨基酚的片剂（多瑞吉平）数分钟后出现过敏反应。对整个制剂进行划痕试验呈阳性，而纯对乙酰氨基酚的试验结果为阴性。因此，对其余药物成分进行了划痕试验，结果显示聚乙烯吡咯烷酮（PVP）是病因。此外，使用斑点印迹技术证实了针对PVP的特异性IgE抗体，从而排除了假过敏反应。该病例强调不仅要考虑活性成分，还要考虑添加剂作为致病因素的必要性。
