Lee A B, Blais B, Shouval H Z, Cooper L N
Institute for Brain and Neural Systems, Departments of Physics and Neuroscience, Brown University, Providence, RI 02912, USA.
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12875-9. doi: 10.1073/pnas.97.23.12875.
The receptive fields for simple cells in visual cortex show a strong preference for edges of a particular orientation and display adjacent excitatory and inhibitory subfields. These subfields are projections from ON-center and OFF-center lateral geniculate nucleus cells, respectively. Here we present a single-cell model using ON and OFF channels, a natural scene environment, and synaptic modification according to the Bienenstock, Cooper, and Munro (BCM) theory. Our results indicate that lateral geniculate nucleus cells must act predominantly in the linear region around the level of spontaneous activity, to lead to the observed segregation of ON/OFF subfields.
视觉皮层中简单细胞的感受野对特定方向的边缘表现出强烈偏好，并显示出相邻的兴奋和抑制子区域。这些子区域分别是来自ON中心和OFF中心外侧膝状体核细胞的投射。在这里，我们提出了一个使用ON和OFF通道、自然场景环境以及根据比恩斯托克、库珀和芒罗（BCM）理论进行突触修饰的单细胞模型。我们的结果表明，外侧膝状体核细胞必须主要在自发活动水平附近的线性区域起作用，才能导致观察到的ON/OFF子区域的分离。
