环境富集对大脑基因表达的影响。
Effects of environmental enrichment on gene expression in the brain.
作者信息
Rampon C, Jiang C H, Dong H, Tang Y P, Lockhart D J, Schultz P G, Tsien J Z, Hu Y
机构信息
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; and the Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. doi: 10.1073/pnas.97.23.12880.
Abstract
An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.
摘要
已知丰富的环境可促进大脑的结构变化，并提高啮齿动物的学习和记忆能力[赫布，D. O.（1947年）《美国心理学家》2，306 - 307页]。为了更好地理解这些依赖于经验的认知变化背后的分子机制，我们使用了高密度寡核苷酸微阵列来分析大脑中的基因表达。大量基因的表达会因丰富训练而发生变化，其中许多基因与神经元结构、突触可塑性和传递有关。这些基因中的一些可能在调节学习和记忆能力方面发挥重要作用。
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