Townsend J M, Fallon G P, Matthews J D, Smith P, Jolin E H, McKenzie N A
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Immunity. 2000 Oct;13(4):573-83. doi: 10.1016/s1074-7613(00)00056-x.
Interleukin-9 is a cytokine produced by Th2 cells and is a candidate gene for asthma and atopy. We have generated IL-9-deficient mice to delineate the specific roles of IL-9 in Th2 responses. Using a pulmonary granuloma model, we have demonstrated a distinct requirement for IL-9 in the rapid and robust generation of pulmonary goblet cell hyperplasia and mastocytosis in response to lung challenge. In contrast, eosinophilia and granuloma formation were not affected. IL-9 was not required for T cell development or differentiation, the generation of naive or antigen-driven antibody responses, or the expulsion of the intestinal parasitic nematode Nippostrongylus brasiliensis. Thus, deletion of IL-9 manifests as a highly defined phenotype in Th2 responses modulating mucus production and mast cell proliferation.
白细胞介素-9是一种由Th2细胞产生的细胞因子，是哮喘和特应性疾病的候选基因。我们已培育出白细胞介素-9缺陷型小鼠，以阐明白细胞介素-9在Th2反应中的具体作用。利用肺部肉芽肿模型，我们已证明在应对肺部刺激时，快速且强烈地产生肺部杯状细胞增生和肥大细胞增多症方面，白细胞介素-9有着独特的需求。相比之下，嗜酸性粒细胞增多和肉芽肿形成未受影响。T细胞发育或分化、天然或抗原驱动的抗体反应的产生，或肠道寄生线虫巴西日圆线虫的驱除均不需要白细胞介素-9。因此，在调节黏液产生和肥大细胞增殖的Th2反应中，白细胞介素-9的缺失表现为一种高度明确的表型。
