Extracellular matrix in development of the early embryo.

The extracellular matrix interacts with cells and promotes and regulates cellular functions such as adhesion, migration, proliferation, differentiation, and morphogenesis. Extracellular molecules are linked to one another by multiple binding domains and form a stable, multifunctional matrix. Cells respond to the extracellular matrix through plasma membrane receptors, which include integrin and non-integrin receptors. The regulation of these interactions requires the coordination of a multiplicity of signals both spatially and temporally.