骨骼肌中的蛋白聚糖

Proteoglycans in skeletal muscle.

Brandan E

Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, P. Universidad Católica de Chile, Santiago.

Braz J Med Biol Res. 1994 Sep;27(9):2109-16.

Abstract

Proteoglycans are macromolecules composed of a protein and one or more chains of sulfated carbohydrates, the glycosaminoglycans. Proteoglycans are found on the cell surface and in the extracellular matrix participating in the cell-cell and cell-extracellular matrix interaction. In this review I present the information accumulated in the past years regarding the presence, characteristics, localization, control of expression and alteration in some pathological states of skeletal muscle proteoglycans. 2. This review presents and discusses current information in this area and some projections for the future in four sections: first, the proteoglycans present in embryonic cells and cell lines from skeletal muscle. Second, the presence of proteoglycans in adult skeletal muscles. Third, the regulation of the expression of skeletal muscle proteoglycans, and fourth, skeletal muscle proteoglycans in pathological conditions.

摘要

蛋白聚糖是由一种蛋白质和一条或多条硫酸化碳水化合物链（即糖胺聚糖）组成的大分子。蛋白聚糖存在于细胞表面和细胞外基质中，参与细胞间以及细胞与细胞外基质的相互作用。在这篇综述中，我将呈现过去几年积累的有关骨骼肌蛋白聚糖的存在、特征、定位、表达调控以及在某些病理状态下的改变的信息。2. 本综述在四个部分呈现并讨论了该领域的当前信息以及对未来的一些预测：第一，存在于胚胎细胞和骨骼肌细胞系中的蛋白聚糖。第二，成年骨骼肌中蛋白聚糖的存在情况。第三，骨骼肌蛋白聚糖表达的调控，第四，病理状态下的骨骼肌蛋白聚糖。