Boccaccio G L
Instituto de Investigaciones Bioquímicas "Fundación Campomar," IIB Buenos Aires, CONICET, IIB-FCEyN, University of Buenos Aires, Buenos Aires, Argentina.
J Neurosci Res. 2000 Nov 15;62(4):473-9. doi: 10.1002/1097-4547(20001115)62:4<473::AID-JNR1>3.0.CO;2-F.
The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and speculates on possible molecular mechanisms for the translational control of myelin-located mRNAs.
编码髓磷脂蛋白的信使核糖核酸（mRNA）在少突胶质细胞突起中的亚细胞定位是髓磷脂形成过程中公认的事实。这些信使在向开启翻译的亚细胞区域移动过程中是如何保持沉默的，仍是一个谜。本综述聚焦于mRNA定位的相关方面，并推测髓磷脂定位mRNA翻译控制的可能分子机制。
