Malter J S
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA.
J Neurosci Res. 2001 Nov 1;66(3):311-6. doi: 10.1002/jnr.10021.
The ability to control gene expression is central to normal development and function. For a growing number of genes in the central nervous system and peripheral tissues, expression is determined by changes in the rate of mRNA decay. At a molecular level, regulated interactions between the mRNA target and sequence-specific binding proteins either inhibit or accelerate decay, affording tight control over gene expression. This review discusses several examples of such posttranscriptional gene regulation.
控制基因表达的能力对于正常发育和功能至关重要。对于中枢神经系统和外周组织中越来越多的基因而言，其表达是由mRNA降解速率的变化所决定的。在分子水平上，mRNA靶标与序列特异性结合蛋白之间的调控相互作用要么抑制要么加速降解，从而对基因表达进行严格控制。本综述讨论了这种转录后基因调控的几个例子。
