Szprynger K, Szczepańska M, Mazur B, Dyduch A, Zwolińska D, Morawiec-Knysak A, Makulska I
Katedry i Kliniki Nefrologii, Endokrynologii i Chorób Metabolicznych Wieku Dzieciecego Slaskiej AM w Zabrzu.
Pol Merkur Lekarski. 2000 Jul;8(49):459-61.
In various pathological conditions elevated serum sialic acid level, as the result of increased metabolism of glycoproteins and glycolipids, is observed. The study aimed at the evaluation of sialic acid concentration in serum of children on continuous ambulatory peritoneal dialysis (CAPD) and maintenance haemodialysis (HD). Examination was performed in 27 end-stage renal disease (ESRD) children including 11 on CAPD, 16 on HD treatment. Ten healthy children served as the control group (K). In CAPD group assessment was carried out during the routine monthly check up, in HD group--before (HD-1) and after (HD-2) dialysis session. Sialic acid concentration was determined using method of Shamberger. In CAPD children we obtained significantly increased serum sialic acid concentration comparing to controls and HD children. Increased serum sialic acid concentration was also found in HD children comparing to controls. There was no significant difference between the sialic acid concentrations before and after dialysis session. Analysis of correlation revealed positive correlation of sialic acid concentration with haemoglobin concentration and hematocrit in CAPD group. In children on HD treatment we showed positive correlation of sialic acid level with renal replacement therapy duration and creatinine concentration after HD. Elevated serum sialic acid concentration in dialysed children could be the result of non-specific organism response, characterised by tissue and organ damage, towards the materials of extracorporeal circulation (HD) or the presence of dialysis solution in peritoneal cavity (CAPD).
在各种病理状态下，由于糖蛋白和糖脂代谢增加，血清唾液酸水平会升高。本研究旨在评估持续非卧床腹膜透析（CAPD）和维持性血液透析（HD）患儿血清中的唾液酸浓度。对27例终末期肾病（ESRD）患儿进行了检查，其中11例接受CAPD治疗，16例接受HD治疗。10名健康儿童作为对照组（K）。在CAPD组，在每月例行检查时进行评估；在HD组，在透析 session 前（HD - 1）和后（HD - 2）进行评估。使用 Shamberger 方法测定唾液酸浓度。与对照组和HD患儿相比，我们发现CAPD患儿的血清唾液酸浓度显著升高。与对照组相比，HD患儿的血清唾液酸浓度也有所升高。透析前后唾液酸浓度无显著差异。相关性分析显示，CAPD组中唾液酸浓度与血红蛋白浓度和血细胞比容呈正相关。在接受HD治疗的患儿中，我们发现唾液酸水平与肾脏替代治疗持续时间和HD后的肌酐浓度呈正相关。透析患儿血清唾液酸浓度升高可能是非特异性机体反应的结果，其特征是组织和器官损伤，是针对体外循环（HD）材料或腹膜腔内透析液的存在（CAPD）。
