Kümpfel T, Then Bergh F, Pollmächer T, Holsboer F, Trenkwalder C
Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany.
Neurology. 2000 Oct 24;55(8):1231-3. doi: 10.1212/wnl.55.8.1231.
The acute effects of a i.m. injection of interferon beta-1a on the secretion of the cytokines interleukin-6, tumor necrosis factor-alpha, soluble tumor necrosis factor receptor I, and interleukin-1 receptor antagonist and its relation to peripheral concentrations of adrenocorticotropic hormone (ACTH) and cortisol in patients with MS were investigated, as well as the influence of cotreatment with indomethacin on these parameters. After interferon beta injection we found an acute rise in plasma cytokine levels and an increase in plasma hormone concentrations, both of which were modulated by indomethacin comedication.
研究了肌肉注射干扰素β-1a对多发性硬化症患者细胞因子白细胞介素-6、肿瘤坏死因子-α、可溶性肿瘤坏死因子受体I和白细胞介素-1受体拮抗剂分泌的急性影响及其与促肾上腺皮质激素（ACTH）和皮质醇外周浓度的关系，以及吲哚美辛联合治疗对这些参数的影响。注射干扰素β后，我们发现血浆细胞因子水平急性升高，血浆激素浓度增加，两者均受到吲哚美辛联合用药的调节。
