Chan A Y, Hooi L S
Department of Medicine and Haemodialysis Unit, Hospital Sultanah Aminah, Johor Bahru.
Med J Malaysia. 2000 Mar;55(1):14-20.
Retrospective analysis was done on 85 patients (76 female, 9 male) with lupus nephritis who started intravenous cyclophosphamide between 1/1/1989 and 31/12/1998. The initial renal biopsy (World Health Organisation) classification was III (4.7%), IV (89.4%) and V (5.9%). Average serum creatinine at time of biopsy was 0.12 +/- 0.12 mmol/l. Median duration of nephritis before biopsy was 2 months (range 0-133). Median duration of follow-up from time of biopsy to outcome (death or end-stage renal failure) was 3.3 years (range 0.3-11.8). Nineteen patients died. The calculated proportion alive at 5 years was 75% and at 10 years 64%. The calculated proportion alive with renal function was 74% and 54% at 5 and 10 years respectively. Fifty-two patients completed cyclophosphamide therapy at the end of the study. There were ten episodes of herpes zoster, the most common infection seen. No malignancy was reported.
对1989年1月1日至1998年12月31日期间开始静脉注射环磷酰胺的85例狼疮性肾炎患者（76例女性，9例男性）进行回顾性分析。初始肾活检（世界卫生组织）分类为III型（4.7%）、IV型（89.4%）和V型（5.9%）。活检时的平均血清肌酐为0.12±0.12 mmol/l。活检前肾炎的中位病程为2个月（范围0 - 133个月）。从活检到结局（死亡或终末期肾衰竭）的中位随访时间为3.3年（范围0.3 - 11.8年）。19例患者死亡。计算得出5年时的存活比例为75%，10年时为64%。计算得出5年和10年时肾功能存活的比例分别为74%和54%。52例患者在研究结束时完成了环磷酰胺治疗。有10例带状疱疹发作，这是最常见的感染情况。未报告有恶性肿瘤。
