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子痫前期

Pre-eclampsia.

作者信息

Walker J J

机构信息

Department of Obstetrics and Gynaecology, St James's University Hospital, Leeds, UK.

出版信息

Lancet. 2000 Oct 7;356(9237):1260-5. doi: 10.1016/S0140-6736(00)02800-2.

Abstract

Pre-eclampsia is associated with significant morbidity and mortality for mother and baby, but it resolves completely post partum. Despite a steady reduction in maternal mortality from the disorder in more developed countries, it remains one of the most common reasons for a woman to die during pregnancy. The disorder starts with a placental trigger followed by a maternal systemic response. Because both this systemic response and the woman's reaction to it are inconsistent, the clinical presentation varies in time and substance, with many different organ systems affected. With the increasing understanding of the disease process, there have been advances in management, such as antihypertensive therapy, magnesium sulphate, and fluid restriction.

摘要

子痫前期与母婴的严重发病率和死亡率相关,但产后会完全缓解。尽管在更发达国家,该疾病导致的孕产妇死亡率稳步下降,但它仍是女性孕期死亡的最常见原因之一。该疾病始于胎盘触发因素,随后引发母体全身反应。由于这种全身反应以及女性对其的反应都不一致,临床表现随时间和实质内容而有所不同,许多不同的器官系统都会受到影响。随着对疾病过程的认识不断加深,在管理方面取得了进展,如抗高血压治疗、硫酸镁和液体限制。

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