Department of Obstetrics & Gynecology, The Edith Wolfson Medical Center, Holon, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Thromb Res. 2013 Jan;131 Suppl 1:S18-21. doi: 10.1016/S0049-3848(13)70013-6.
Inadequate placental development results in pregnancy complications. The extent and the degree of defective deep placentation may explain why a similar insult would result in different clinical presentations. The relative new categorization of the placental lesions, separating the non-infectious lesions into lesions that are consistent with maternal and fetal circulation abnormalities, and the infectious lesions into maternal and fetal inflammatory responses, provides us an additional tool to determine the placental maternal and fetal role in the various pregnancy complications. Placental vascular lesions are different in pregnancies complicated by preeclampsia (predominant maternal vascular supply lesions), by fetal growth restriction (FGR) (predominant fetal vascular supply lesions), and by preeclampsia with FGR (both maternal and fetal compartments are involved). Moreover, placental vascular lesions are also different in relation to gestational age at disease onset, as in early- and late-onset preeclampsia, FGR, Fetal death and preterm labor.
胎盘发育不全可导致妊娠并发症。胎盘深部植入缺陷的程度和范围可能解释了为何类似的损伤会导致不同的临床表现。胎盘病变的相对新分类将非传染性病变分为与母体和胎儿循环异常一致的病变，将传染性病变分为母体和胎儿炎症反应，为我们提供了另一种工具，可用于确定胎盘在各种妊娠并发症中的母体和胎儿作用。伴有子痫前期的妊娠（主要为母体血管供应病变）、胎儿生长受限（FGR）（主要为胎儿血管供应病变）和子痫前期合并 FGR（母体和胎儿均受累）的胎盘血管病变不同。此外，胎盘血管病变与疾病发病时的孕龄也有关系，如早发型和晚发型子痫前期、FGR、胎儿死亡和早产。
