del Fresno M, El-Faham A, Carpino L A, Royo M, Albericio F
Departament de Química Orgànica, Universitat de Barcelona, 08028 Barcelona, Spain.
Org Lett. 2000 Nov 16;2(23):3539-42. doi: 10.1021/ol006322p.
The guanidine moiety is an important motif present in many biologically active compounds. Fully substituted guanidines are of key importance for the development of bioactive molecules. The present paper reports on an efficient procedure for the direct solid-phase conversion of amines to fully substituted guanidines under very mild conditions.
胍基部分是许多生物活性化合物中存在的重要结构单元。全取代胍对于生物活性分子的开发至关重要。本文报道了一种在非常温和的条件下将胺直接固相转化为全取代胍的有效方法。
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