固相合成新型含 Trp(Nps)二肽衍生物作为 TRPV1 通道阻断剂。
Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers.
机构信息
Instituto de Química Médica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain.
出版信息
Molecules. 2010 Jul 15;15(7):4924-33. doi: 10.3390/molecules15074924.
Abstract
Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
摘要
Trp(Nps)-Lys-NH(2) 衍生物，无论是在 N 末端还是在 Lys 侧链上，或者在这两个位置上都带有烷基或胍基，可以在固相上方便地制备，并作为 TRPV1 通道拮抗剂进行评估。
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