使用乙烯型 Pictet-Spengler 环化反应制备六氢苯并[f]异喹啉
Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous pictet-spengler cyclization.
作者信息
Cesati R R, Katzenellenbogen J A
机构信息
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
出版信息
Org Lett. 2000 Nov 16;2(23):3635-8. doi: 10.1021/ol006533u.
PMID:11073663
Abstract
A vinylogous Pictet-Spengler cyclization has been carried out using activated aldehydes, ketones, and alkynes to prepare a variety of substituted hexahydrobenzo[f]isoquinolines. A unique set of conditions was utilized to effect efficient cyclization with acid-sensitive electrophiles.
摘要
已使用活化的醛、酮和炔烃进行了乙烯型 Pictet-Spengler 环化反应，以制备各种取代的六氢苯并[f]异喹啉。利用一组独特的条件实现了与酸敏感亲电试剂的有效环化。
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