乙烯基同型 Pictet-Spengler 环化反应的发展及（±）-Lundurine A 的全合成。
Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)-Lundurine A.
机构信息
Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9038, USA.
出版信息
Angew Chem Int Ed Engl. 2018 Jun 4;57(23):6888-6891. doi: 10.1002/anie.201803702. Epub 2018 May 4.
Abstract
A novel vinylogous Pictet-Spengler cyclization has been developed for the generation of indole-annulated medium-sized rings. The method enables the synthesis of tetrahydroazocinoindoles with a fully substituted carbon center, a prevalent structural motif in many biologically active alkaloids. The strategy has been applied to the total synthesis of (±)-lundurine A.
摘要
发展了一种新型的 vinylogous Pictet-Spengler 环化反应，用于生成吲哚并环合的中环。该方法能够合成具有完全取代的碳中心的四氢氮杂并吲哚，这是许多生物活性生物碱中常见的结构基序。该策略已应用于(±)-lundurine A 的全合成。
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