Wang T J, Liang M H, Sangha O, Phillips C B, Lew R A, Wright E A, Berardi V, Fossel A H, Shadick N A
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA 02115, USA.
Clin Infect Dis. 2000 Nov;31(5):1149-54. doi: 10.1086/317465. Epub 2000 Nov 6.
Previous studies suggest that concurrent Lyme disease and babesiosis produce a more sever illness than either disease alone. The majority of babesiosis infections, however, are subclinical. Our objective was to characterize on the basis of a total-population survey of Nantucket Island, Massachusetts, whether coexposure to Lyme disease and babesiosis causes more severe illness or poorer long-term outcomes than Lyme disease alone. In this retrospective cohort study, residents indicating a history of Lyme disease were compared with randomly selected population controls on a standardized medical history, blinded physical examination, and serological studies for Borrelia burgdorferi and Babesia microti. Serological evidence of exposure to babesiosis was not associated with increased severity of acute Lyme disease. The groups did not differ with regard to the prevalence of constitutional, musculoskeletal, or neurological symptoms a mean of 6 years after acute Lyme disease. Prior Lyme disease and serological exposure to B. microti are not associated with poorer long-term outcomes or more persistent symptoms Lyme disease alone.
先前的研究表明，莱姆病和巴贝斯虫病同时感染所导致的疾病比单独感染这两种疾病中的任何一种都更为严重。然而，大多数巴贝斯虫病感染是亚临床的。我们的目标是，基于对马萨诸塞州楠塔基特岛的全人群调查，确定与单独感染莱姆病相比，同时接触莱姆病和巴贝斯虫病是否会导致更严重的疾病或更差的长期预后。在这项回顾性队列研究中，将有莱姆病病史的居民与随机选择的人群对照组在标准化病史、盲法体格检查以及针对伯氏疏螺旋体和微小巴贝斯虫的血清学研究方面进行比较。接触巴贝斯虫病的血清学证据与急性莱姆病严重程度增加无关。在急性莱姆病平均6年后，两组在全身性、肌肉骨骼或神经系统症状的患病率方面没有差异。既往莱姆病以及血清学上接触微小巴贝斯虫与单独感染莱姆病相比，不会导致更差的长期预后或更持续的症状。
