Delahanty D L, Raimonde A J, Spoonster E
Department of Psychology, Kent State University, (DLD), Kent, Ohio 44242, USA.
Biol Psychiatry. 2000 Nov 1;48(9):940-7. doi: 10.1016/s0006-3223(00)00896-9.
This study was designed to examine the relationship between urinary hormone levels collected upon admission to the trauma unit following a motor vehicle accident and posttraumatic stress disorder symptomatology 1 month later.
Fifteen-hour urine samples were collected from 63 male and 36 female motor vehicle accident victims and were used to assess levels of catecholamines and cortisol reflecting peritraumatic and acute-phase posttraumatic levels. Presence of posttraumatic stress disorder symptomatology was assessed 1 month after the accident.
Motor vehicle accident victims subsequently diagnosed with acute posttraumatic stress disorder excreted significantly lower levels of cortisol in 15-hour urines collected upon admission to the hospital. In addition, urinary levels of cortisol predicted a significant percentage of the variance in intrusive and avoidant thoughts 1 month after the accident.
The results of our study suggest that initial cortisol levels in the immediate aftermath of a traumatic event contribute, in part, to subsequent symptoms of posttraumatic stress disorder.
本研究旨在探讨机动车事故后进入创伤科时所采集的尿激素水平与1个月后创伤后应激障碍症状之间的关系。
收集了63名男性和36名女性机动车事故受害者15小时的尿液样本，用于评估反映创伤期间和创伤后急性期的儿茶酚胺和皮质醇水平。在事故发生1个月后评估创伤后应激障碍症状的存在情况。
随后被诊断为急性创伤后应激障碍的机动车事故受害者，在入院时采集的15小时尿液中皮质醇水平显著较低。此外，事故发生1个月后，尿皮质醇水平预测了侵入性和回避性思维中很大比例的变异。
我们的研究结果表明，创伤事件刚发生后的初始皮质醇水平部分导致了随后的创伤后应激障碍症状。
