Susic D, Sparks J C, Machado E A
J Lab Clin Med. 1976 Feb;87(2):232-9.
The antihypertensive action of renomedullary autotransplantation was investigated in rats with unilateral hereditary hydronephrosis showing extensive destruction of the medulla of the affected kidney. All rats were divided into three groups and unilaterally nephrectomized. The first group consisted of rats with a normal kidney remaining. The second and third groups had the hydronephrotic kidney remaining and received renomedullary and renocortical autotransplants, respectively. After completion of baseline studies, all rats were given 1 per cent saline solution instead of drinking water, and relevant parameters were re-examined 14 days later. Significant increase in blood pressure (greater than 150 mm. Hg), extracellular fluid volume, and plasma volume were found in group 3 while no changes were detected in groups 1 and 2. After administration of aspirin (and presumed blockade of prostaglandin synthesis) significant increases in plasma and extracellular fluid volumes were detected in groups 1 and 2, but no change in blood pressure was found. The results show that renomedullary transplantation protects against salt-induced hypertension and further indicate that the renomedullary prostaglandins are not a likely mediator of the antihypertensive action of the renal medulla.
在患有单侧遗传性肾积水且患侧肾脏髓质广泛破坏的大鼠中，研究了肾髓质自体移植的降压作用。所有大鼠均分为三组并进行单侧肾切除术。第一组大鼠保留一个正常肾脏。第二组和第三组保留肾积水的肾脏，分别接受肾髓质和肾皮质自体移植。在完成基线研究后，所有大鼠均给予1%的盐溶液代替饮用水，并在14天后重新检查相关参数。在第三组中发现血压（大于150毫米汞柱）、细胞外液量和血浆量显著增加，而第一组和第二组未检测到变化。在给予阿司匹林（并假定阻断前列腺素合成）后，在第一组和第二组中检测到血浆和细胞外液量显著增加，但血压未发现变化。结果表明，肾髓质移植可预防盐诱导的高血压，并进一步表明肾髓质前列腺素不太可能是肾髓质降压作用的介质。
