Mojica W D, Kuntzman T
Department of Pathology, William Beaumont Hospital, Royal Oak, Michigan 48073-6769, USA.
Diagn Cytopathol. 2000 Dec;23(6):393-6. doi: 10.1002/1097-0339(200012)23:6<393::aid-dc6>3.0.co;2-m.
Elastofibroma is a slow-growing soft tissue lesion characteristically found between the inferior scapula and chest wall. Because it behaves clinically in a benign manner, fine-needle aspiration (FNA) represents the simplest and quickest method of obtaining a definitive diagnosis, thus obviating more invasive means of obtaining a tissue diagnosis. However, due to the nature of this lesion a correct diagnosis can inadvertently be missed. Herein we describe the findings of a recent FNA that obtained abundant diagnostic material and elaborate upon the spectrum of cytologic features of the elastic fibers that can be identified. These features should be recognized, since aspiration biopsy in elastofibromas can lead to hypocellular smears. In addition, we discuss recent developments in the pathophysiology of elastic fibers and their application toward understanding the generation of an elastofibroma.
弹力纤维瘤是一种生长缓慢的软组织病变，典型地位于肩胛下角与胸壁之间。由于其临床行为呈良性，细针穿刺抽吸活检（FNA）是获得明确诊断的最简单、最快捷的方法，从而避免了采用更具侵入性的手段来获取组织诊断。然而，由于该病变的性质，可能会无意中漏诊。在此，我们描述了近期一次FNA的结果，此次FNA获取了丰富的诊断材料，并详细阐述了可识别的弹性纤维的细胞特征谱。应认识到这些特征，因为弹力纤维瘤的穿刺活检可能导致涂片细胞过少。此外，我们讨论了弹性纤维病理生理学的最新进展及其在理解弹力纤维瘤发生方面的应用。
