Antimalarial amino alcohols II: anthraceneaminoethanols and anthraceneaminopropanols (1- and 9-substituted).
作者信息
Traxler J T, Moats M J, Lira E P, Huffman C W
出版信息
J Pharm Sci. 1975 Dec;64(12):1943-9. doi: 10.1002/jps.2600641207.
PMID:1107515
Abstract
The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the light of previously published work.
摘要
相似文献
1
Antimalarial amino alcohols II: anthraceneaminoethanols and anthraceneaminopropanols (1- and 9-substituted).
J Pharm Sci. 1975 Dec;64(12):1943-9. doi: 10.1002/jps.2600641207.
2
Synthesis and antimalarial activity of anthracene amino alcohols.
J Med Chem. 1974 May;17(5):563-5. doi: 10.1021/jm00251a028.
3
Synthesis of halogenated anthraldehydes and their conversion to antimalarial amino alcohols.
J Med Chem. 1972 Aug;15(8):861-3. doi: 10.1021/jm00278a025.
4
Antimalarials. 4. Trichloronaphthalene amino alcohols.抗疟药。4. 三氯萘氨基醇。
J Med Chem. 1979 Jan;22(1):86-9. doi: 10.1021/jm00187a019.
5
Antimalarial phenanthrene amino alcohols. 3. Halogen-containing 9-phenanthrenemethanols.
J Med Chem. 1975 Oct;18(10):1011-9. doi: 10.1021/jm00244a012.
6
Further side-chain modification of antimalarial phenanthrene amino alcohols.
J Med Chem. 1973 Oct;16(10):1093-6. doi: 10.1021/jm00268a006.
7
Difference in antimalarial activity between certain amino alcohol diastereomers.
J Med Chem. 1976 Jan;19(1):170-2. doi: 10.1021/jm00223a032.
8
Antimalarial phenanthrene amino alcohols. 2. Trifluoromethyl-containing 9-phenanthrenemethanols.抗疟菲氨基醇。2. 含三氟甲基的9-菲甲醇。
J Med Chem. 1972 Jul;15(7):775-80. doi: 10.1021/jm00277a019.
9
Antimalarials. 3. 1,2,4-Triazines.抗疟药。3. 1,2,4-三嗪类。
J Med Chem. 1976 Jun;19(6):845-8. doi: 10.1021/jm00228a024.
10
Antimalarial arylaminopropanols.抗疟芳基氨基丙醇类化合物。
J Med Chem. 1972 Jul;15(7):771-5. doi: 10.1021/jm00277a018.
Zotero 插件