Savilov P N
N.N. Burdenko Voronezh State Medical Academy.
Vopr Med Khim. 2000 Jul-Aug;46(4):370-6.
The experiments have shown that even resection of relatively small (15-20%) portion of the intact liver resulted in significant changes of glutamine metabolism in hepatocytes, which were not eliminated for 21 days of postoperative period. The changes of the activity of key enzymes of glutamine metabolism, glutamine synthetase and glutaminase (phosphate-dependent), are responsible for these alterations. The changes of activity of these enzymes closely depend on the location of hepatocytes to focus of mechanical damage.
实验表明，即使切除完整肝脏相对较小（15 - 20%）的部分，也会导致肝细胞谷氨酰胺代谢发生显著变化，且在术后21天内这些变化并未消除。谷氨酰胺代谢关键酶谷氨酰胺合成酶和谷氨酰胺酶（磷酸依赖性）活性的变化是这些改变的原因。这些酶活性的变化紧密依赖于肝细胞与机械损伤灶的位置关系。
