Maugeri D, Santangelo A, Barbagallo P, Bonanno M R, Malaguarnera M, Rizza I, Speciale S, Tomarchio M, Curasì M P, Panebianco P
Institute of Internal Medicine and Geriatrics University of Catania, Italy.
Eur Rev Med Pharmacol Sci. 1999 Sep-Oct;3(5):211-6.
Numerous studies have suggested a marked correlation between thyroid functionality indices and lipid metabolism. In this trial we assessed the functional parameters of 165 individuals over 70, 87 women and 78 men, correlating the serum values of T3, T4, FT4, TSH with cholesterol, triglycerides, HDL, Apo-A and Apo-B levels. The correlation was performed over the whole population studied and subsequently, after dividing the population by sex and age (3 age groups: A, 70-75; B, 76-80; C, over 80) in the individual groups. In the population as a whole, we have observed a statistically significant correlation between T4/cholesterol (P=0.0001); T3/cholesterol (P=0.06); T4/triglycerides (P=0.0001); T3/triglycerides (P=0.09); T4/HDL (P=0.0001); T4/Apo-A (P= 0.02); T3/Apo-A (P=0.008); T4/Apo-B (P=0.0001). Analysis by gender shows a statistically significance between the female and male sexes in the correlation between T3/cholesterol (P=0.001); T3/triglycerides (P=0.06); T4/cholesterol (P=0.0001) and T4/triglycerides (P=0.0001). When the data were analyzed by age, in Group A (75-80) there was no statistically significant correlation, whereas in Group B (76-80) there has been an increase in significance in the correlation between T3/cholesterol (P=0.006); T3/triglycerides (P=0.001); T3/Hdl (P=0.08); T3/Apo-A (P=0.0001); T3/Apo-B (P=0.08); T4/cholesterol (P=0.00001) and ); T4/Apo-A (P=0.0001). On the other hand in the Group C age group (over 80) this significance is considerably lower. Maybe this decrease of correlations should be attributed to a global savings of the older organisms, or to a process of natural selection.
众多研究表明，甲状腺功能指标与脂质代谢之间存在显著相关性。在本试验中，我们评估了165名70岁以上个体的功能参数，其中87名女性和78名男性，将血清中T3、T4、FT4、TSH的值与胆固醇、甘油三酯、高密度脂蛋白、载脂蛋白A和载脂蛋白B的水平进行关联分析。在整个研究人群中进行了相关性分析，随后按性别和年龄（3个年龄组：A组，70 - 75岁；B组，76 - 80岁；C组，80岁以上）将人群分为各个组后再次进行分析。在整个人群中，我们观察到T4/胆固醇（P = 0.0001）；T3/胆固醇（P = 0.06）；T4/甘油三酯（P = 0.0001）；T3/甘油三酯（P = 0.09）；T4/高密度脂蛋白（P = 0.0001）；T4/载脂蛋白A（P = 0.02）；T3/载脂蛋白A（P = 0.008）；T4/载脂蛋白B（P = 0.0001）之间存在统计学显著相关性。按性别分析显示，在T3/胆固醇（P = 0.001）；T3/甘油三酯（P = 0.06）；T4/胆固醇（P = 0.0001）和T4/甘油三酯（P = 0.0001）的相关性方面，女性和男性之间存在统计学显著性差异。当按年龄分析数据时，A组（75 - 80岁）没有统计学显著相关性，而在B组（76 - 80岁）中，T3/胆固醇（P = 0.006）；T3/甘油三酯（P = 0.001）；T3/高密度脂蛋白（P = 0.08）；T3/载脂蛋白A（P = 0.0001）；T3/载脂蛋白B（P = 0.08）；T4/胆固醇（P = 0.00001）和T4/载脂蛋白A（P = 0.0001）之间的相关性显著性增加。另一方面，在C组（80岁以上）年龄组中，这种显著性要低得多。也许这种相关性的降低应归因于老年生物体的整体节约，或者是自然选择的过程。
