Cortés-Blanco A, Mayayo Dehesa E, Ferrández Longás A, Labarta Aizpún J I, Martínez-Lázaro R
Unidad de Endocrinología Pediátrica, Hospital Infantil Miguel Servet, Zaragoza, España.
An Esp Pediatr. 1999 Oct;51(4):361-8.
The purpose of this study was to estimate the basal serum concentration reference values for total T3 (T3), total T4 (T4), free T4 (FT4), thyrotropin (TSH) and thyroglobulin (Tg) in healthy children of Zaragoza.
Healthy children aged 0 to 14, with normal weight and height, living in the metropolitan area of Zaragoza (Spain) were the reference population of this transversal study. Basal serum concentrations of T3, T4 and FT4 were measured by radioimmunoassay and of TSH and Tg by immunoradiometric assay. Reference values and ranges were estimated according to the recommendations of the International Federation of Clinical Chemistry.
Reference values have been classified according to age, sex and pubertal stage. There are differences in T3, T4, FT4 TSH and Tg concentrations during the prepubertal period according to age, but not to sex, and between the prepubertal period and puberty. Sex and Tanner stage influence T3 and T4 concentrations during puberty.
Since there are differences in T3, T4, FT4, TSH and Tg reference values according to age, sex, pubertal stage and immunoassays, it is necessary to establish reference values for every population and laboratory in accordance with these parameters.
本研究旨在估算萨拉戈萨健康儿童血清中总三碘甲状腺原氨酸（T3）、总甲状腺素（T4）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和甲状腺球蛋白（Tg）的基础浓度参考值。
本横断面研究的参考人群为居住在萨拉戈萨（西班牙）大都市区、年龄在0至14岁之间、体重和身高正常的健康儿童。采用放射免疫分析法测定血清中T3、T4和FT4的基础浓度，采用免疫放射分析法测定TSH和Tg的基础浓度。参考值和范围根据国际临床化学联合会的建议进行估算。
参考值已根据年龄、性别和青春期阶段进行分类。青春期前阶段，T3、T4、FT4、TSH和Tg浓度随年龄变化而不同，但与性别无关，且青春期前阶段与青春期之间存在差异。性别和坦纳分期会影响青春期期间T3和T4的浓度。
由于T3、T4、FT4、TSH和Tg的参考值因年龄、性别、青春期阶段和免疫分析方法而异，因此有必要根据这些参数为每个群体和实验室建立参考值。
