Schnitzler E, Spörl E, Seiler T
Augenklinik des Universitätsklinikums Carl Gustav Carus, Technischen Universität Dresden.
Klin Monbl Augenheilkd. 2000 Sep;217(3):190-3. doi: 10.1055/s-2000-10344.
Corneal melting is a serious condition and in many cases maybe managed only by surgery. UV-radiation with Riboflavin is a new method that may stop the melting process of the cornea.
Four patients suffering from melting ulcera of the cornea of various origin underwent a single UV-radiation. Two ultraviolet diodes were used emitting light with an wavelength of 370 nm with an energy of 2.5 mW/cm2. The radiation time was 30 minutes. Before he radiation was performed 2-3 drops of 0.11% Riboflavinsolution were applied to the cornea. The treatment area was 6-7 mm in diameter.
After the treatment in three of the four patients the melting process of the cornea stopped. At least temporarily, a surgical procedure could be delayed.
Because of the absence of any side-effects in serious cases the method is recommended prior to surgery.
角膜融解是一种严重的病症，在许多情况下可能只能通过手术来治疗。核黄素紫外线照射是一种可能阻止角膜融解过程的新方法。
4例不同病因的角膜融解性溃疡患者接受了单次紫外线照射。使用了两个紫外线二极管，发射波长为370nm、能量为2.5mW/cm²的光。照射时间为30分钟。在进行照射前，向角膜滴入2-3滴0.11%的核黄素溶液。治疗区域直径为6-7mm。
4例患者中有3例在治疗后角膜融解过程停止。至少在短期内，可以推迟手术。
由于在严重病例中没有任何副作用，因此建议在手术前采用该方法。
