Ghenciu Laura Andreea, Faur Alexandra Corina, Bolintineanu Sorin Lucian, Salavat Madalina Casiana, Maghiari Anca Laura
Department III Functional Sciences, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no. 2, 300041 Timisoara, Romania.
Department IX Surgery, Discipline of Ophtalmology, Victor Babes University of Medicine and Pharmacy, E. Murgu Sq., no. 2, 300041 Timisoara, Romania.
Microorganisms. 2024 Jan 13;12(1):161. doi: 10.3390/microorganisms12010161.
Fungal keratitis represents a potentially sight-threatening infection associated with poor prognosis, as well as financial burden. Novel diagnostic methods include polymerase-chain-reaction (PCR)-based approaches, metagenomic deep sequences, in vivo confocal microscopy, and antifungal susceptibility testing. The ideal therapeutic approaches and outcomes have been widely discussed in recent times, with early therapy being of the utmost importance for the preservation of visual acuity, minimizing corneal damage and reducing the scar size. However, combination therapy can be more efficacious compared to monotherapy. Understanding the pathogenesis, early diagnosis, and prevention strategies can be of great importance. In this narrative, we discuss the recent progress that may aid our understanding of the diagnosis, treatment, and prevention of mycotic keratitis.
真菌性角膜炎是一种潜在的威胁视力的感染性疾病，预后较差，还会带来经济负担。新型诊断方法包括基于聚合酶链反应（PCR）的方法、宏基因组深度测序、体内共聚焦显微镜检查以及抗真菌药敏试验。近年来，理想的治疗方法和治疗效果已得到广泛讨论，早期治疗对于保护视力、将角膜损伤降至最低以及减小瘢痕大小至关重要。然而，联合治疗可能比单一疗法更有效。了解发病机制、早期诊断和预防策略可能非常重要。在本综述中，我们讨论了可能有助于我们理解真菌性角膜炎诊断、治疗和预防的最新进展。
